Unravelling chronic obstructive pulmonary disease

The chronic lung disease COPD affects between 4-10% of Europeans, but about 70% of them are underdiagnosed: a major public health problem. By developing a simulation environment of the respiratory system and creating a decision-support system for clinicians, the European research project SYNERGY-COPD wants to improve diagnosis and management of the disease. The system allows doctors to anticipate the progression of COPD and to determine the most suitable treatment for each COPD patient. Doctors can also make use of a patented algorithm, developed within the project, to assess the quality of the Spirometry tests of their patients.

Three clinical studies were conducted: a retrospective study on two databases of 13 and 5 million patients; a prospective study on over 400 COPD patients; and a third combining these two. The results indicate the high potential of a systems approach to address COPD heterogeneity. Significant knowledge gaps were identified that are relevant to shape strategies to foster 4P Medicine for patients with COPD.

Fermoselle C, Rabinovich R, Ausín P, Puig-Vilanova E, Coronell C, Sanchez F, Roca J, Gea J, Barreiro E. Does oxidative stress modulate limb muscle atrophy in severe COPD patients? Eur Respir J. 2012 Oct;40(4):851-62
Rodriguez DA, Kalko S, Puig-Vilanova E, Perez-Olabarría M, Falciani F, Gea J, Cascante M, Barreiro E, Roca J. Muscle and blood redox status after exercise training in severe COPD patients. Free Radic Biol Med. 2012 Jan 1;52(1):88-94.
Public dissemination: SYNERGY-COPD - www.youtube.com/watch;

Avicenna Alliance news

Avicenna present at the European Research & Innovation Days

The European Research and Innovation days was a three-day event in Brussels, during which researchers, academics, businesses,...

find out more ›

SAVE THE DATE! Ansys-FDA-Avicenna event in Washington on 11 October 2019

Innovation through healthcare simulationFor those of you who will be in Washington mid-October, ANSYS, in cooperation with the...

find out more ›

Avicenna answers online consultation to shape Horizon Europe

On 23 July the Avicenna Alliance has submitted its opinion to on the strategic priorities of Horizon Europe, the EU’s next framework...

find out more ›

Prestigious FDA award allocated to group that developed the V&V 40 standard

The Avicenna Alliance is proud to announce that some of its working group members have received the FDA Crosscutting Group...

find out more ›

Show all activites

Sign up for our monthly newsletter!


Sign up