Avicenna Alliance : Publications

Avicenna Alliance Glossary of Terms for Computer Modeling and Simulation

There are occasional confusions and diverging opinions possibly leading to misunderstanding in the use of some In Silico concepts in the literature. To clarify our message, a team of academic and industry members of the Avicenna Alliance, led by Martha De Cunha Maluf-Burgman from Edwards Lifesciences, is proposing a definition of words regularly used in the ‘In Silico’ literature to clarify the meaning of the terms we are using in our publications.

This Glossary is a first release with a first short list of definitions; more concepts will be defined, and existing definitions may be adjusted in future updates of this document.

Avicenna_Alliance_Glossary_of_Terms_for_Computer_Modeling_and_Simulation.pdf (pdf, 701 KB)

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The Role of Artificial Intelligence within In Silico Medicine

A range of authors across academia and industry, representing both the Avicenna Alliance and the Virtual Physiological Human Institute, have produced a new white paper on the potential of computer modelling and simulation in healthcare, with a particular focus on the role of Artificial Intelligence, that is intended to stimulate policy making, regulatory thinking and research strategies in this exciting space.

The past decade has produced overwhelming evidence about the importance of digital healthcare: well-defined clinical endpoints utilizing novel digital biomarkers can quantify the evolution of individuals’ health status; this approach will lead to predictive and prescriptive capabilities in many cases. This white paper discusses the potential of #computer modelling and simulation in healthcare, generally referred to as “in silico medicine”, with a particular focus on the role of Artificial Intelligence (AI). ...

AI_in_health_-_White_Paper.pdf (pdf, 1 MB)

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Toward a Regulatory Pathway for Using In Silico Trials in CE Marking Position Paper

A team of researchers of the In Silico World project, including several key Avicenna Alliance members, led by Prof. Francesco Pappalardo (University of Catania), Avicenna Alliance’ Pharmaceutical Strategy TF Co-Chair, recently published a Position Paper in IEEE Journal of Biomedical and Health Informatics (J-BHI). In Silico Trials (IST) plays a growing role in the development of new medical devices. This position paper reviews the current system for IST and recommends that the EU regulatory system should innovate to avoid more innovative companies to focus on other large markets.

Toward_a_Regulatory_Pathway_for_the_Use_of_in_Silico_Trials_in_The_Ce_Marking_of_Medical_Devices.pdf (pdf, 623 KB)

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Members of the European Parliament call EU Health Commissioner to place in silico medicine on her policy agenda from 2021 onwards!

On 22 June, a group of five Members of the European Parliament (MEPs) sent a letter to Commissioner for Health, Stella Kyriakides to call for action on computer modelling and simulation (CM&S).

The new Avicenna position paper on in silico evidence in the regulatory approval of medical devices is out!

The Avicenna Alliance is proud to announce the recent publication of its new position paper entitled Ensuring the Quality of in silico Evidence: Application to Medical Devices. This document provides a broad explanation of the opportunities and benefits of in silico methods while also drawing attention to the urgent need for a harmonised regulatory approach supporting the acceptance of in silico evidence included in device submissions. The paper then outlines a risk-based framework for establishing the credibility requirements of in silico evidence used during regulatory decision-making.

Avicenna_Alliance_Position_paper_in_silico_evidence_application_to_Medical_Devices.pdf (pdf, 1 MB)

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The new Avicenna flyer is out!

The past few weeks, the Alliance has been working hard to develop a brand-new Avicenna flyer for public distribution. The flyer aims at giving anyone who is yet unfamiliar with the Alliance, a concise overview of its origins, purpose, activities, mission, and long-term vision. Moreover, the flyer explains why in silico is so important for the Alliance’s objectives, as well as what it could potentially bring to our future healthcare systems. All members are kindly invited to distribute the leaflet to anyone who could be interested.

P80303001246-0421_AVI_In_Silico_Flyer_4P_Web.pdf (pdf, 1 MB)

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Avicenna Alliance news

24 January 2023

Working Group Leaders elections

Our warmest congratulations to Liesbet Geris and Mark Palmer for their reappointment as Working Group Leaders of the Avicenna's Research & Technology Working Group and...

Publications

Avicenna Alliance Glossary of Terms for Computer Modeling and Simulation

The Role of Artificial Intelligence within In Silico Medicine

Toward a Regulatory Pathway for Using In Silico Trials in CE Marking Position Paper

Members of the European Parliament call EU Health Commissioner to place in silico medicine on her policy agenda from 2021 onwards!

The new Avicenna position paper on in silico evidence in the regulatory approval of medical devices is out!

The new Avicenna flyer is out!

Avicenna Alliance news

Working Group Leaders elections

We are delighted to welcome NumeriCor as a new Avicenna member!

Avicenna Alliance Glossary of Terms for Computer Modeling and Simulation

THE ROLE OF ARTIFICIAL INTELLIGENCE WITHIN IN SILICO MEDICINE

Toward a regulatory pathway for Using in Silico Trials in CE Marking of Medical Devices

Avicenna Alliance response to the ICHE11A Consultation

Avicenna Alliance Feedback to the European Health Data Space Call for Feedback

We are honored to welcome Zimmer Biomet as a new Avicenna’s member!

Avicenna Alliance Response to 2023 Stakeholders' Targeted Consultation on EU4Health

New Avicenna APAC Task Force

Cécile De Coster is the new Avicenna Pharmaceutical Strategy Task Force Co-chair

Avicenna Alliance goes on growing by welcoming Edwards Lifesciences as a new member!

Avicenna Alliance is honoured to welcome Alfasigma as a new member!

EU-funded project successfully develops AI software that grows and treats cancerous tumors

In silico used to validate Omicron variant detection method!

The priorities of the upcoming French Presidency of the Council of the European Union - what’s new for Avicenna?

New Avicenna UK Insilico Regulatory Innovation Task Force

In Silico in Innovation – again!

Avicenna Alliance meets with MEPs to discuss in silico medicine

The Joint Research Centre advocates for a “paradigm change” to in silico research methods!

The European Commission Joint Research Centre publishes a public knowledge base of non-animal models used in immuno-oncology

The State of the (European) Union

The BECA Beat

Avicenna Alliance prepares for the next EU policy session

Joint Research Centre of the Commission launches report on national strategies for Artificial Intelligence!

Conference of the Slovenian Council Presidency addresses digital twin technologies and digitalisation in healthcare!

WHO issues first global report on use of AI in healthcare

Slovenian Presidency of the Council of the EU launches its six-month programme!

Members of the European Parliament call EU Health Commissioner to place in silico medicine on her policy agenda from 2021 onwards!

Our new position paper on in silico evidence in the regulatory approval of medical devices is out!

Happy 5th Anniversary to the Avicenna Alliance!

EU New Medical Device Regulation now in force! In silico mentioned for the first time

The European Commission adopts Communication on Europe's global approach to cooperation in research and innovation

Avicenna Alliance provides feedback on the European Commissions’ roadmap for the revision of the EU general pharmaceuticals legislation

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Happy 5^th Anniversary to the Avicenna Alliance!

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